The poor healing capacity of soft tissues in general and soft tissue interfaces in particular motivates the need for a sustained therapeutic delivery system specifically tailored to address the unique problems of tissue repair. Due to the composition and complexity of tissues, the ideal system would recapitulate the microstructure of the native tissue while also providing biochemical cues throughout the repair process to direct cellular activity and tissue remodeling. To this end, our group designs tunable multifactorial and spatial delivery of biochemical factor for long-term tissue repair. We are particularly interested in interfacial tissue healing, such as the musculotendinous junction, and the innovative design is remised on nanofibrous matrices for tissue integration that sequester regional depots of biofactor-releasing microspheres to locally regulate cellular activity throughout interfacial tissue repair.
Biocompatibility and Bioactivity of an FGF-Loaded Microsphere-Based Bilayer Delivery System
Kim, DH., Huegel J., Taylor BL., Nuss C., Weiss S., Soslowsky LJ, Mauck R., Kuntz AF. Acta Biomaterialia (2020) [DOI]
Localized Delivery of Ibuprofen via a Bilayer Delivery System (BiLDS) for Supraspinatus Tendon Healing in a Rat Model
Taylor, BL, Kim DH, Huegel J, Burkholder S, Weiss S, Nuss C, Raja H, Soslowsky LJ, Mauck RL, Kuntz AF, Bernstein J. Journal of Orthopaedic Research (2020) [DOI]