The idea behind biomimetic matrices, such as pre-vascularized scaffolds, is to mimic the structural and biological processes during musculoskeletal tissue development and design functional biomimetic structures such as decellularized pre-vascularized osteonic structures which promote stable blood vessel formation in vivo throughout bone healing.
Decellularized Cortical Bone Scaffold Promotes Organized Neovascularization In Vivo
Taylor, B.L., Indano, S., Yankannah, Y., Patel, P., Perez, I., Freeman, J.W. Tissue Engineering Part A. 25(13-14):p. 964-977 (2019) [DOI]
Three-Dimensional Porous Trabecular Scaffold Exhibits Osteoconductive Behaviors in Vitro
Taylor, B.L., Perez, X., Ciprano, J., Freeman, O., Goldstein, A., Freeman, J.W. Regenerative Engineering and Translational Medicine (2019) [DOI]