The idea behind biomimetic matrices, such as pre-vascularized scaffolds, is to mimic the structural and biological processes during musculoskeletal tissue development and design functional biomimetic structures such as decellularized pre-vascularized osteonic structures which promote stable blood vessel formation in vivo throughout bone healing.

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Decellularized Cortical Bone Scaffold Promotes Organized Neovascularization In Vivo
Taylor, B.L., Indano, S., Yankannah, Y., Patel, P., Perez, I., Freeman, J.W. Tissue Engineering Part A. 25(13-14):p. 964-977 (2019) [DOI]

Three-Dimensional Porous Trabecular Scaffold Exhibits Osteoconductive Behaviors in Vitro
Taylor, B.L., Perez, X., Ciprano, J., Freeman, O., Goldstein, A., Freeman, J.W. Regenerative Engineering and Translational Medicine (2019) [DOI]