Tendon fibrosis results in reduced functionality and increased risk of re-injury, yet the cellular and molecular mechanisms driving tendon healing remain incompletely understood. Healing is regulated by both extrinsic and intrinsic cell activities, often leading to fibrotic tissue with poor mechanical integrity. Extracellular vesicles (EVs), which mediate cell-to-cell communication and transport bioactive molecules, have emerged as key players in tissue repair. However, the specific role of EVs in modulating tendon fibrosis remains largely unexplored. This work aims to investigate how different microenvironments influence EV phenotype and function in healthy and diseased in vitro tendon models.
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Diseased Tendon Models Demonstrate Influence of Extracellular Matrix Alterations on Extracellular Vesicle Profile
Kariman A. Shama, Zachary Franklin Greenberg, Chadine Tammame, Mei He, and Brittany L. Taylor Bioengineering (Basel) (2025)
[DOI]
[PubMed]
